Introduction. The article provides a system and statistical analysis of emergency situations associated with fires at nuclear power plants (NPPs) in various countries of the world for the period from 1955 to 2019. The countries, where fires occurred at nuclear power plants, were identified (the USA, Great Britain, Switzerland, the USSR, Germany, Spain, Japan, Russia, India and France). Facilities, exposed to fires, are identified; causes of fires are indicated. The types of reactors where accidents and incidents, accompanied by large fires, have been determined.The analysis of major emergency situations at nuclear power plants accompanied by large fires. During the period from 1955 to 2019, 27 large fires were registered at nuclear power plants in 10 countries. The largest number of major fires was registered in 1984 (three fires), all of them occurred in the USSR. Most frequently, emergency situations occurred at transformers and cable channels — 40 %, nuclear reactor core — 15 %, reactor turbine — 11 %, reactor vessel — 7 %, steam pipeline systems, cooling towers — 7 %. The main causes of fires were technical malfunctions — 33 %, fires caused by the personnel — 30 %, fires due to short circuits — 18 %, due to natural disasters (natural conditions) — 15 % and unknown reasons — 4 %. A greater number of fires were registered at RBMK — 6, VVER — 5, BWR — 3, and PWR — 3 reactors.Conclusions. Having analyzed accidents, involving large fires at nuclear power plants during the period from 1955 to 2019, we come to the conclusion that the largest number of large fires was registered in the USSR. Nonetheless, to ensure safety at all stages of the life cycle of a nuclear power plant, it is necessary to apply such measures that would prevent the occurrence of severe fires and ensure the protection of personnel and the general public from the effects of a radiation accident.